Description of C18 Alkaline HPLC Columns
The C18 Alkaline HPLC columns are a new generation of different selective C18 developed by Hawach. It has hydrophobic interaction and electrostatic interaction. It has a hydrophilic group embedded in it to make it hydrophilic. The hydrophilic group replaces a large amount of silicon.
This HPLC column is widely used for basic compounds. The alcohol-based site can effectively prevent the interaction between the alkaloid and the silanol group, and the alkaline substance has a good peak shape.
Characteristics of C18 Alkaline HPLC Columns
Octadecylsilyl silica gel HPLC column
Relatively weaker polarity than C8 HPLC column
The peak shape of the alkaline substance is better, and the material having a poor peak shape on the conventional double-sealed C18 has a better peak shape;
The rapid separation of similar samples by the mobile phase is hydrophilic, and the mobile phase of the high water ratio can be used, which is extremely stable.
Bonded phase: C18 (USP L1)
Particle size: 3μm, 5μm
Specific surface area: 320m²/g (120Å)
Carbon loading: 12% (120Å)
Sealing: Double tailing
pH stability: 1.5-10.0